1-Bromo-3-chloropropane → 9-(3-Chloropropyl)-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine

HRID 590490Notes

Reaction equation

HRID 590490 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4]CN1C(OC)=NC2C1=NC(O[C@@H](C)CC)=NC=2N.FC(F)(F)C(O)=O.[CH3:30][C@H:31]([O:35][C:36]1[N:44]=[C:43]2[C:39]([N:40]=[C:41]([O:45][CH3:46])[NH:42]2)=[C:38]([NH2:47])[N:37]=1)[CH2:32][CH2:33][CH3:34].BrCCCCl>>[Cl:1][CH2:2][CH2:3][CH2:4][N:42]1[C:41]([O:45][CH3:46])=[N:40][C:39]2[C:43]1=[N:44][C:36]([O:35][C@@H:31]([CH3:30])[CH2:32][CH2:33][CH3:34])=[N:37][C:38]=2[NH2:47]

Participants

4

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 592526489-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amineHCID 178448286HCID 178448286, compound

Product 1

HCID 592525739-(3-Chloropropyl)-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 44 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine trifluoroacetate and 1-bromo-3-chloropropane.

Sources & evidence

ORD record
ord-4365689837604c3ab856a2a3ceb56ef4
Source dataset
uspto-grants-2016_01
Patent number
US09233962B2

Reaction notes

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