Piperidine → 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[4-(1-piperidinyl)butyl]-7,9-dihydro-8H-purin-8-one

HRID 590497Notes

Reaction equation

HRID 590497 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@H:9]([O:13][C:14]1[NH:15][C:16]([NH2:25])=[C:17]2[C:21]([N:22]=1)=[N:20][C:19]([O:23]C)=[N:18]2)[CH2:10][CH2:11][CH3:12].Br[CH2:27][CH2:28][CH2:29][CH2:30]Cl.[NH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[NH2:25][C:16]1[N:15]=[C:14]([O:13][C@@H:9]([CH3:8])[CH2:10][CH2:11][CH3:12])[N:22]=[C:21]2[C:17]=1[NH:18][C:19](=[O:23])[N:20]2[CH2:27][CH2:28][CH2:29][CH2:30][N:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 813641-Bromo-4-chlorobutaneHCID 178448285HCID 178448285, compound

Product 1

HCID 448165656-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[4-(1-piperidinyl)butyl]-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 19 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1-bromo-4-chlorobutane and piperidine.

Sources & evidence

ORD record
ord-ca4f56b5d2b449448a5c19de506394da
Source dataset
uspto-grants-2016_01
Patent number
US09233962B2

Reaction notes

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