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HRID59055

反应详情

EQUATION

反应方程式

HRID 59055 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)[O-]
HCID175

Acetate

C2H3O2-

结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@]2(C)C(n4cnc5ccccc54)=CC[C@@H]32)C1
HCID11464592

Androsta-5,16-dien-3-ol, 17-(1H-benzimidazol-1-yl)-, 3-acetate, (3β)-

C28H34N2O2

PRODUCTS

生成物

1
结构：C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3cnc4ccccc43)=CC[C@@H]12
HCID11188409

3-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene

C26H32N2O

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Compound 5 prepared by following general method C, treating acetate solution of 15 (1 g 3.02 mmol) in methanol (15 mL) with 10% methanolic KOH (5 mL) for 1.5 h. Purification by FCC over short column provided pure 5 with identical spectral and analytical data as we previously reported.

WORKUP

后处理

  1. customPurification by FCC over short column
  2. customprovided pure 5 with identical spectral and analytical data as we