HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetate → Galeterone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetate | HCID 175 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | (3S,8R,9S,10R,13S,14S)-17-(1H-Benzo[D]imidazol-1-YL)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[A]phenanthren-3-YL acetate | HCID 11464592 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Galeterone | HCID 11188409 | — |
Reaction Steps
Compound 5 prepared by following general method C, treating acetate solution of 15 (1 g 3.02 mmol) in methanol (15 mL) with 10% methanolic KOH (5 mL) for 1.5 h. Purification by FCC over short column provided pure 5 with identical spectral and analytical data as we previously reported.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439912B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-219de467e34b4d72ad05d9e2ef510967 |
| Source note | uspto-grants-2016_09 |