Hydrochloric Acid → 4-Amino-3,3-dimethylbutanoic acid hydrochloride
Reaction equation
[CH3:1][C:2]1([CH3:8])[CH2:6][NH:5][C:4](=[O:7])[CH2:3]1.[ClH:9].[OH2:10]>>[ClH:9].[NH2:5][CH2:6][C:2]([CH3:8])([CH3:1])[CH2:3][C:4]([OH:10])=[O:7]Participants
4
Conditions
- Temperature
- 120 °C
Procedure
4,4-Dimethyl-2-pyrrolidinone (2.52 g, 22.3 mmol) was added to a mixture of concentrated HCl (50 mL) and water (50 mL) and the resulting mixture was refluxed at 120° C. for 20 hours. After it was cooled to room temperature, the mixture was washed twice with dichloromethane. The aqueous layer was evaporated to give 4-amino-3,3-dimethyl-butyric acid hydrochloride compound 55-B (3.4 g) as a white solid.
Workup
- temperatureAfter it was cooled to room temperature
- washthe mixture was washed twice with dichloromethane
- customThe aqueous layer was evaporated
Sources & evidence
- ORD record
- ord-fe4e5b253dc44a3a9e5d33c685798b0b
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09233978B2
Reaction notes
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