Trifluoroacetic acid → HCID 79091612, compound

HRID 590575Notes

Reaction equation

HRID 590575 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:19][CH:7]2[CH2:8][N:9](C(OC(C)(C)C)=O)[CH2:10][CH2:11][N:6]2[C:5]1=[O:20].C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:1][CH2:2][CH2:3][N:4]1[CH2:19][CH:7]2[CH2:8][NH:9][CH2:10][CH2:11][N:6]2[C:5]1=[O:20]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118358759HCID 118358759, compound

Product 1

HCID 79091612HCID 79091612, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 2-(2-hydroxyethyl)-3-oxo-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazine-7-carboxylate (Compound 67-D) (1 mmol) was dissolved in CH2Cl2 (3 mL) followed by the slow addition of TFA (1 mL) at 0° C. The reaction mixture was stirred at rt for 1 hour and then the solvent was removed in vacuum to give the crude product 70-A, which was used directly in the next step.

Workup

  1. customthe solvent was removed in vacuum

Sources & evidence

ORD record
ord-2b887f94263142b6a45dceeafaf8c436
Source dataset
uspto-grants-2016_01
Patent number
US09233978B2

Reaction notes

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