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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 590576Generated: October 30, 2026

2-Chlorobenzaldehyde → methyl (4R)-6-(bromomethyl)-4-(2-chlorophenyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate

https://huagongshe.com/reaction/590576

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-ChlorobenzaldehydeHCID 6996—
ReactantMethyl (R)-6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylateHCID 89995948—
Productmethyl (4R)-6-(bromomethyl)-4-(2-chlorophenyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylateHCID 118358766—

Reaction Steps

Compound C-2 was prepared in analogy to compound C by using 2-chlorobenzaldehyde instead of 2-chloro-4-fluorobenzaldehyde.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09233978B2
Source datasetuspto-grants-2016_01
ORD IDord-a7dcb6ff980549a693e6bcf091a5b780
Source noteuspto-grants-2016_01