反应详情

温度

50 °C

To a solution of 4-(((3,3-difluorocyclobutyl)methoxy)methyl)-6-(1-ethoxyvinyl)-N-(3-methoxy-4-(6-methylpyridazin-4-yl)phenyl)pyrimidin-2-amine (104 mg, 0.21 mmol) in dioxane (15 mL) were added water (1 mL) and HCl (conc. 0.052 mL, 0.63 mmol). The mixture was stirred at 50° C. for 20 minutes. The solvent was evaporate and 50% saturated aqueous sodium bicarbonate solution was added. The mixture was extracted with DCM. The organic phase was separated on phase separator and evaporated to give the title compound (94 mg, 95%).

1. customThe solvent was evaporate
2. addition50% saturated aqueous sodium bicarbonate solution was added
3. extractionThe mixture was extracted with DCM
4. customThe organic phase was separated on phase separator
5. customevaporated