反应详情

温度

50 °C

To a solution of 4-((1,3-difluoropropan-2-yloxy)methyl)-6-(1-ethoxyvinyl)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)pyrimidin-2-amine (47 mg, 0.10 mmol) in dioxane (7.5 mL) was added water (0.5 mL) and HCl (conc., 0.025 mL, 0.31 mmol). The mixture was stirred at 50° C. for 20 minutes. The solvents were evaporated. Sodium bicarbonate solution (50% saturated) was added and the mixture was extracted with DCM. The organic phase was separated on phase separator and evaporated to give the title compound (34 mg, 77%).

1. customThe solvents were evaporated
2. additionSodium bicarbonate solution (50% saturated) was added
3. extractionthe mixture was extracted with DCM
4. customThe organic phase was separated on phase separator
5. customevaporated