Phenethylamine → N-Benzyl-2-chloro-N-methyl-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine

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Reaction Steps

To a solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (200 mg, 0.77 mmol) in acetonitrile (3 mL) was benzylmethylamine (0.296 mL, 2.30 mmol) added. The reaction was stirred at ambient temperature for 30 minutes. The solvent was evaporated. The mixture was purified by preparative HPLC the title compound (194 mg, 73%).

Provenance & Evidence