反应详情

温度

120 °C

A mixture of 2-chloro-4-(1-ethoxyvinyl)-6-((3,3,3-trifluoropropoxy)methyl)pyrimidine (89 mg, 0.29 mmol), 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (58 mg, 0.29 mmol), cesium carbonate (187 mg, 0.57 mmol), palladium (II) acetate (10 mg, 0.04 mmol) and (2-biphenylyl)dicyclohexylphosphine (15 mg, 0.04 mmol) in dioxane (3 mL) was heated at 120° C. under argon for 90 minutes in microwave reactor. The mixture was passed through a short silica plug which was eluted with EtOAc. The residue was purified by preparative HPLC to give the title compound as a dry film 93 mg (68%).

1. washwas eluted with EtOAc
2. customThe residue was purified by preparative HPLC