6-Chloropicolinic acid → N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-6-chloropicoline amide

HRID 590916Notes

Reaction equation

HRID 590916 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8](Cl)=[O:9])[N:3]=1.ClC1C=CC=C(C(O)=O)N=1.S(Cl)(Cl)=O.[Br:25][C:26]1[CH:32]=[C:31]([C:33]([F:42])([C:38]([F:41])([F:40])[F:39])[C:34]([F:37])([F:36])[F:35])[CH:30]=[C:29]([C:43]([F:46])([F:45])[F:44])[C:27]=1[NH2:28]>>[Br:25][C:26]1[CH:32]=[C:31]([C:33]([F:42])([C:34]([F:36])([F:37])[F:35])[C:38]([F:39])([F:41])[F:40])[CH:30]=[C:29]([C:43]([F:44])([F:45])[F:46])[C:27]=1[NH:28][C:8](=[O:9])[C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[N:3]=1

Participants

5

Reactant 4

HCID 208126-Chloropicolinic acidHCID 24386Thionyl ChlorideHCID 109429766-chloropyridine-2-carbonyl ChlorideHCID 582975582-Bromo-4-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)-6-(trifluoromethyl)benzenamine

Product 1

HCID 86654246N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-6-chloropicoline amide

Procedure

According to the method of 1-3 of Example 1, a target compound was prepared from 2-chloropyridine-6-carboxylic acid chloride prepared from 2-chloropyridine-6-carboxylic acid and thionyl chloride, and 2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)aniline obtained in 1-2 of Example 1.

Workup

  1. customobtained in 1-2 of Example 1

Sources & evidence

ORD record
ord-d3e8011c0ff54b32a1ab50774b349f6f
Source dataset
uspto-grants-2016_01
Patent number
US09237745B2

Reaction notes

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