Hydrochloric Acid → 2-Aminothiazole-4-carboxylic acid

HRID 590918Notes

Reaction equation

HRID 590918 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9]CC)=[O:8])[N:6]=1.[OH-].[Na+].Cl>>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 73216Ethyl 2-aminothiazole-4-carboxylate

Product 1

HCID 15018822-Aminothiazole-4-carboxylic acidYield 85%

Procedure

To 40 ml of an aqueous solution of 4.00 g (23.2 mmol) of ethyl 2-aminothiazole-4-carboxylate was added 1.86 g (46.5 mmol) of sodium hydroxide, followed by stirring at room temperature for 5 hours. The reaction liquid was adjusted to pH 1 by the addition of concentrated hydrochloric acid, and the precipitated crystals were collected by filtration to prepare 2.84 g (yield 85%) of a target compound.

Workup

  1. customThe reaction liquid
  2. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-f648e0ac8df0466382782d46d10593b6
Source dataset
uspto-grants-2016_01
Patent number
US09237745B2

Reaction notes

Loading…