Cyclopropylamine → HCID 117820988, compound

HRID 59105Notes

Reaction equation

HRID 59105 reaction equation
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.[Cl:5][C:6]1[N:11]=[C:10](Cl)[CH:9]=[C:8]([CH2:13][O:14][CH2:15][C:16]([F:19])([F:18])[F:17])[N:7]=1>CO.C(#N)C>[Cl:5][C:6]1[N:11]=[C:10]([NH:4][CH:1]2[CH2:3][CH2:2]2)[CH:9]=[C:8]([CH2:13][O:14][CH2:15][C:16]([F:19])([F:17])[F:18])[N:7]=1

Participants

5

Reactant 2

HCID 69828CyclopropylamineHCID 1178209122,4-Dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine

Product 1

HCID 117820988HCID 117820988, compoundYield 57%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6342AcetonitrileSolvent

Procedure

A solution of cyclopropanamine (68 mg, 1.20 mmol) in MeOH (2 mL) was added dropwise to an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (104 mg, 0.40 mmol) in acetonitrile (2 mL). The mixture was stirred at rt overnight. The mixture was purified by preparative HPLC yielding to give the title compound (64 mg, 57%).

Workup

  1. customThe mixture was purified by preparative HPLC
  2. customyielding

Sources & evidence

ORD record
ord-087ad64615354752ab74578fb962e75a
Source dataset
uspto-grants-2016_09
Patent number
US09439904B2

Reaction notes

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