HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → HCID 117820988, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 2,4-Dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine | HCID 117820912 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 117820988 | HCID 117820988 | 57% |
Reaction Steps
A solution of cyclopropanamine (68 mg, 1.20 mmol) in MeOH (2 mL) was added dropwise to an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (104 mg, 0.40 mmol) in acetonitrile (2 mL). The mixture was stirred at rt overnight. The mixture was purified by preparative HPLC yielding to give the title compound (64 mg, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439904B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-087ad64615354752ab74578fb962e75a |
| Source note | uspto-grants-2016_09 |