反应详情

Using the procedure described in example 29, step 2, ethyl tert-butoxy-[4-(2-chloro-phenyl)-2,5-dimethyl-thiophen-3-yl]-acetate (28f) (110 mg, 0.29 mmol) is converted, after purification by flash chromatography on silica gel (dichloromethane/methanol 95/5), to tert-butoxy-[4-(2-chloro-phenyl)-2,5-dimethyl-thiophen-3-yl]-acetic acid (example 51) (67 mg, 0.19 mmol, 67%).

1. customafter purification by flash chromatography on silica gel (dichloromethane/methanol 95/5)