HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 70818507, compound → Tert-butoxy-[4-(2-chloro-phenyl)-2,5-dimethyl-thiophen-3-yl]-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 70818507 | HCID 70818507 | — |
| Reactant | HCID 70819373 | HCID 70819373 | — |
| Product | Tert-butoxy-[4-(2-chloro-phenyl)-2,5-dimethyl-thiophen-3-yl]-acetic acid | HCID 70818348 | — |
Reaction Steps
Using the procedure described in example 29, step 2, ethyl tert-butoxy-[4-(2-chloro-phenyl)-2,5-dimethyl-thiophen-3-yl]-acetate (28f) (110 mg, 0.29 mmol) is converted, after purification by flash chromatography on silica gel (dichloromethane/methanol 95/5), to tert-butoxy-[4-(2-chloro-phenyl)-2,5-dimethyl-thiophen-3-yl]-acetic acid (example 51) (67 mg, 0.19 mmol, 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238026B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-86efcdfb709c44a8b88c1b2540c08e6e |
| Source note | uspto-grants-2016_01 |