反应详情

温度

120 °C

3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (0.066 g, 0.32 mmol), 2-chloro-5-methyl-4-(2,2,2-trifluoroethoxy)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (0.11 g, 0.32 mmol), palladium(II) acetate (11 mg, 0.05 mmol), 2-(dicyclohexylphosphino)biphenyl (0.017 g, 0.05 mmol) and cesium carbonate (0.212 g, 0.65 mmol) were mixed in dioxane (3 mL). The vial was capped, evacuated and flushed with nitrogen. The mixture was heated by microwave irradiation at 120° C. for 1.5 h. The mixture was filtered and the residue was purified by column chromatography on silica eluting with a gradient of methanol in DCM to give the title compound 135 mg (82%).

1. customThe vial was capped
2. customevacuated
3. customflushed with nitrogen
4. filtrationThe mixture was filtered
5. customthe residue was purified by column chromatography on silica eluting with a gradient of methanol in DCM