反应详情

温度

50 °C

To a solution of 4-(1-ethoxyvinyl)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-6-(methoxymethyl)pyrimidin-2-amine (172 mg, 0.43 mmol) in 1,4-dioxane (30 mL) were added water (2 mL) and hydrochloric acid (conc., 0.11 mL, 1.30 mmol). The mixture was stirred at 50° C. for 20 min. The solvents were evaporated. Sodium bicarbonate (aq, 50% saturated) was added and the mixture was extracted with DCM. The organic phase was separated on phase separator and the solvents were evaporated to give the title compound, 160 mg (100%).

1. customThe solvents were evaporated
2. additionSodium bicarbonate (aq, 50% saturated) was added
3. extractionthe mixture was extracted with DCM
4. customThe organic phase was separated on phase separator
5. customthe solvents were evaporated