HCID 66747471, compound → HCID 66823294, compound

HRID 591186Notes

Reaction equation

HRID 591186 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:15]([C:17]2([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[CH2:20][CH2:19][CH2:18]2)=[O:16])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([C:17]2([C:15]([C:11]3[CH:12]=[CH:13][CH:14]=[C:9]([OH:8])[CH:10]=3)=[O:16])[CH2:20][CH2:19][CH2:18]2)=[CH:22][CH:23]=1

Participants

4

Reactant 1

HCID 66747471HCID 66747471, compound

Product 1

HCID 66823294HCID 66823294, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

(3-Benzyloxy-phenyl)-[1-(4-chloro-phenyl)-cyclobutyl]-methanone (780 mg, 2 mmol) was dissolved in ethyl acetate, containing Pd/C (80 mg, 10% on C). Hydrogenation was performed at room temperature during 4 hours. Reaction was filtered through celite and the solvent evaporated. The product (548 mg) was used in the next step without further purification.

Workup

  1. customReaction
  2. filtrationwas filtered through celite
  3. customthe solvent evaporated
  4. customThe product (548 mg) was used in the next step without further purification

Sources & evidence

ORD record
ord-0d8f22ae89bb4f8796bb15c5a72dff62
Source dataset
uspto-grants-2016_01
Patent number
US09238619B2

Reaction notes

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