反应详情

温度

50 °C

To a solution of 4-((cyclopropylmethoxy)methyl)-6-(1-ethoxyvinyl)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)pyrimidin-2-amine (98 mg, 0.23 mmol) in dioxane (15 mL) were added water (1 mL) and hydrochloric acid (conc., 0.056 mL, 0.68 mmol). The mixture was stirred at 50° C. for 20 min. The solvents were evaporated. Sodium bicarbonate (aq, 50% saturated) was added and the mixture was extracted with DCM. The organic phase was separated on phase separator and the solvents were evaporated to give the title compound 90 mg (98%).

1. customThe solvents were evaporated
2. additionSodium bicarbonate (aq, 50% saturated) was added
3. extractionthe mixture was extracted with DCM
4. customThe organic phase was separated on phase separator
5. customthe solvents were evaporated