反应详情

温度

120 °C

2-Chloro-4-(1-ethoxyvinyl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (0.10 g, 0.34 mmol) was dissolved in dioxane (5 mL). 3-Methoxy-4-(2-methyloxazol-5-yl)aniline (0.069 g, 0.34 mmol), cesium carbonate (0.220 g, 0.67 mmol), palladium(II) acetate (0.011 g, 0.05 mmol) and 2-(dicyclohexylphosphino)biphenyl (0.018 g, 0.05 mmol) were added. The vial was capped, evacuated and flushed with nitrogen. The mixture was heated by microwave irradiation at 120° C. for 1.5 h. The solvents were evaporated. EtOAc was added and the mixture was filtered through a plug of silica. The solvents were evaporated and the residue was purified by column chromatography on silica eluting with EtAOc to give the title compound as a solid, 138 mg (88%).

1. customThe vial was capped
2. customevacuated
3. customflushed with nitrogen
4. customThe solvents were evaporated
5. additionEtOAc was added
6. filtrationthe mixture was filtered through a plug of silica
7. customThe solvents were evaporated
8. customthe residue was purified by column chromatography on silica eluting with EtAOc