Water → HCID 69135266, compound

HRID 591264Notes

Reaction equation

HRID 591264 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[O:17])=[CH:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].O>C(O)C>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][OH:17])=[CH:14][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 57431992HCID 57431992, compound

Product 1

HCID 69135266HCID 69135266, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-[3-(benzyloxy)propyl]benzaldehyde (1.86 g, 7.31 mmol) in ethanol (28 mL), sodium borohydride (83 mg, 2.19 mmol) was slowly added at room temperature. The mixture was stirred for 1 h. Water (50 mL) was added, and the mixture was extracted with ethyl acetate (3×50 mL), dried over magnesium sulfate and concentrated in vacuo. The crude product was used without purification.

Workup

  1. extractionthe mixture was extracted with ethyl acetate (3×50 mL)
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated in vacuo
  4. customThe crude product was used without purification

Sources & evidence

ORD record
ord-730efe2c226d4ce9b20d03f1c8ddbff0
Source dataset
uspto-grants-2016_01
Patent number
US09238631B2

Reaction notes

Loading…