反应详情

A mixture of 540 mg (2.51 mmol) 5-benzyloxy-2-pyridinemethanol (prepared according to J. Med. Chem. 1977, 20, 1258-1262), 536 mg N-bromo succinimide (3.01 mmol), and 1.2 g polymer bound triphenylphosphine (loading approx. 3 mmol/g, approx. 3.3 mmol) in dichloromethane (40 mL) was stirred overnight at room temperature. All solids were removed by filtration, and the filtrate was washed with aqueous sodium bicarbonate and water, and than concentrated in vacuo. The crude product (540 mg of a slightly pink solid, 79% crude yield) was used without further purification.

1. customAll solids were removed by filtration
2. washthe filtrate was washed with aqueous sodium bicarbonate and water
3. concentrationthan concentrated in vacuo
4. customThe crude product (540 mg of a slightly pink solid, 79% crude yield) was used without further purification