反应详情

Palladium(II) acetate (0.5 mg, 0.002 mmol) was added to a solution of 1 (15.0 mg, 0.0472 mmol) and 3,3,4,4,5,5,6,6,6-nonafluorohex-1-ene (8.9 mg, 0.089 mmol) in 0.44 g of 95% aqueous ethanol. The reaction mixture was stirred at room temperature for 1 d and filtered through a pad of Celite 545. Removal of the solvent gave a pale yellow oil which was purified by SiO2 column chromatography with hexane to give 7a as colorless oil (17.1 mg; 81%): IR (ATR): {tilde over (v)}=2918, 2849, 1663, 1234, 1134, 844 cm−1. MS (GC, EI): m/z=448 [M+], 429 [M+-F], 302 [M+-SF6], 279 [M+-C3F7], 152 [M+-C3F12S]. 1H NMR (500 MHz, CDCl3): δ=7.80 (d, J=8.7 Hz, 2H), 7.57 (d, J=8.7 Hz, 2H), 7.20 (d, J=16.2 Hz, 1H), 6.30 (dt, J=16.2, 12.0 Hz, 1H) ppm. 13C NMR (125 MHz, CDCl3): δ=154.7 (C), 137.7 (CH), 136.5 (C), 127.8 (2CH), 126.7 (2CH), 117.7 (CH) ppm. 19F NMR (470 MHz, CDCl3): δ=83.4 (quint, J=150 Hz, 1 F), 62.6 (d, J=150 Hz, 4 F), −81.0 (s, 3 F), −112.0 (s, 2 F), −124.0 (s, 2 F), −125.7 (s, 2 F) ppm.

1. filtrationfiltered through a pad of Celite 545
2. customRemoval of the solvent
3. customgave a pale yellow oil which
4. customwas purified by SiO2 column chromatography with hexane