Sodium Hydroxide → (4-Chloro-6-((1,3-dimethyl-1H-pyrazol-5-yl)methoxy)-1-benzothiophen-3-yl)acetic acid

Participants

Reaction Steps

To a mixture of methyl(4-chloro-6-((1,3-dimethyl-1H-pyrazol-5-yl)methoxy)-1-benzothiophen-3-yl)acetate (162 mg) and EtOH (3 mL) was added 1N NaOH (1 mL) at room temperature, and the mixture was refluxed for 1 h. The mixture was concentrated in vacuo, neutralized with 1N HCl at 0° C. and extracted with EtOAc. The organic layer was separated, washed successively with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was crystallized from EtOAc-hexane to give the title compound (141 mg).

Provenance & Evidence