反应详情

温度

130 °C

1-(2-Chloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-yl)-2-methylpropan-1-ol (20 mg, 0.07 mmol), 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (13.61 mg, 0.07 mmol), palladium(II) acetate (2.255 mg, 10.04 μmol),2-(dicyclohexylphosphino)biphenyl (3.52 mg, 10.04 μmol), and cesium carbonate (43.6 mg, 0.13 mmol) were mixed in dioxane (3 mL). The vial was flushed with nitrogen, capped and heated by microwave irradiation at 130° C. for 2.5 h. The mixture was filtered through a pad of silica gel, the pad was eluted with DCM and 5% MeOH in DCM. The solvents were evaporated. The residue was purified by preparative HPLC to give the title compound as a dry film, 9 mg (27%).

1. customThe vial was flushed with nitrogen
2. customcapped
3. filtrationThe mixture was filtered through a pad of silica gel
4. washthe pad was eluted with DCM and 5% MeOH in DCM
5. customThe solvents were evaporated
6. customThe residue was purified by preparative HPLC