Ammonia → HCID 118667024, compound

HRID 591494Notes

Reaction equation

HRID 591494 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[C:10]2[CH:11]=[CH:12][C:13]([O:15][CH2:16][C:17]3[C:18](Cl)=[N:19][C:20]([CH3:23])=[N:21][CH:22]=3)=[CH:14][C:9]=2[S:8][CH:7]=1)[CH3:2].[NH3:26]>CCO>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[C:10]2[CH:11]=[CH:12][C:13]([O:15][CH2:16][C:17]3[C:18]([NH2:26])=[N:19][C:20]([CH3:23])=[N:21][CH:22]=3)=[CH:14][C:9]=2[S:8][CH:7]=1)[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 118667016HCID 118667016, compound

Product 1

HCID 118667024HCID 118667024, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of ethyl(6-((4-chloro-2-methylpyrimidin-5-yl)methoxy)-1-benzothiophen-3-yl)acetate (100 mg) and 2M ammonia in EtOH (10 mL) was stirred at 100° C. for 5 h under microwave irradiation. The mixture was concentrated in vacuo. The residual solid was recrystallized from EtOAc-IPE to give the title compound (92 mg).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customThe residual solid was recrystallized from EtOAc-IPE

Sources & evidence

ORD record
ord-7341ab6168f740c2a66e10d6bb96e3b9
Source dataset
uspto-grants-2016_01
Patent number
US09238639B2

Reaction notes

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