Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 118667016 | HCID 118667016 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 118667024 | HCID 118667024 | — |
Reaction Steps
A mixture of ethyl(6-((4-chloro-2-methylpyrimidin-5-yl)methoxy)-1-benzothiophen-3-yl)acetate (100 mg) and 2M ammonia in EtOH (10 mL) was stirred at 100° C. for 5 h under microwave irradiation. The mixture was concentrated in vacuo. The residual solid was recrystallized from EtOAc-IPE to give the title compound (92 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09238639B2 |
|---|
| Source dataset | uspto-grants-2016_01 |
|---|
| ORD ID | ord-7341ab6168f740c2a66e10d6bb96e3b9 |
|---|
| Source note | uspto-grants-2016_01 |
|---|
