Sodium borohydride → HCID 89775320, compound

HRID 591540Notes

Reaction equation

HRID 591540 reaction equation
[CH3:1][O:2][C:3](=[O:27])[CH2:4][C:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=3[Cl:26])=[C:13]([C:14](=[O:16])[CH3:15])[C:8]=2[O:7][CH:6]=1.[BH4-].[Na+]>CO>[CH3:1][O:2][C:3](=[O:27])[CH2:4][C:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=3[Cl:26])=[C:13]([CH:14]([OH:16])[CH3:15])[C:8]=2[O:7][CH:6]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 118667063HCID 118667063, compound

Product 1

HCID 89775320HCID 89775320, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of methyl(7-acetyl-6-((2,4-dichlorobenzyl)oxy)-1-benzofuran-3-yl)acetate (100 mg) in MeOH (2.5 mL) was added NaBH4 (10.2 mg). The mixture was stirred at room temperature for 20 min. The mixture was quenched with water. The resulting solid was collected by filtration to give the title compound (89 mg).

Workup

  1. customThe mixture was quenched with water
  2. filtrationThe resulting solid was collected by filtration

Sources & evidence

ORD record
ord-b71c184961d941b08666dd3191ae9f7a
Source dataset
uspto-grants-2016_01
Patent number
US09238639B2

Reaction notes

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