HCID 89768032, compound → HCID 89767861, compound

HRID 591550Notes

Reaction equation

HRID 591550 reaction equation
[OH:1][CH2:2][CH:3]([C:8]1[C:12]2[CH:13]=[CH:14][C:15]([O:17]CC3C=CC(OC)=CC=3)=[CH:16][C:11]=2[O:10][CH:9]=1)[C:4]([O:6][CH3:7])=[O:5]>[Pd].CO>[OH:1][CH2:2][CH:3]([CH:8]1[C:12]2[CH:13]=[CH:14][C:15]([OH:17])=[CH:16][C:11]=2[O:10][CH2:9]1)[C:4]([O:6][CH3:7])=[O:5]

Participants

4

Reactant 1

HCID 89768032HCID 89768032, compound

Product 1

HCID 89767861HCID 89767861, compoundYield 96.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a mixture of methyl 3-hydroxy-2-(6-((4-methoxybenzyl)oxy)-1-benzofuran-3-yl)propanoate (86.9 mg) and MeOH (2.4 mL) was added 10% palladium on carbon (15 mg). The mixture was hydrogenated under balloon pressure for 21 h. The catalyst was removed by filtration and concentrated to give the title compound (56.0 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-0215ecaf60804880a6e1852dd01a4c52
Source dataset
uspto-grants-2016_01
Patent number
US09238639B2

Reaction notes

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