Hydrochloric Acid → HCID 136262657, compound

HRID 591590Notes

Reaction equation

HRID 591590 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[C:9]2[C:4]=1[C:5](=[O:34])[NH:6][C:7]([C:15]1[CH:20]=[CH:19][C:18]([CH:21]3[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]3)=[CH:17][CH:16]=1)=[N:8]2.Cl>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[C:9]2[C:4]=1[C:5](=[O:34])[NH:6][C:7]([C:15]1[CH:16]=[CH:17][C:18]([CH:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)=[CH:19][CH:20]=1)=[N:8]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136262659HCID 136262659, compound

Product 1

HCID 136262657HCID 136262657, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl 4-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidine-1-carboxylate (11) (0.45 mmol) in 1,4-dioxane (2 mL) was added 4 M HCl in 1,4-dioxane (1 mL). The resulting solution was stirred at room temperature for 5 hours. Then, the mixture was concentrated in vacuo and the resulting material was purified by flash chromatography on silica gel to afford compound 5,7-dimethoxy-2-(4-(piperidin-4-yl)phenyl)quinazolin-4(3H)-one (12).

Workup

  1. concentrationThen, the mixture was concentrated in vacuo
  2. customthe resulting material was purified by flash chromatography on silica gel

Sources & evidence

ORD record
ord-62e5163a28af4c3bb88ee69db15a975c
Source dataset
uspto-grants-2016_01
Patent number
US09238640B2

Reaction notes

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