反应详情

温度

120 °C

A mixture of 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (91 mg, 0.45 mmol), 2-chloro-N-cyclopropyl-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine (63 mg, 0.22 mmol), cesium carbonate (146 mg, 0.45 mmol), palladium(II) acetate (8 mg, 0.03 mmol) and 2-(dicyclohexyl-phosphino)biphenyl (12 mg, 0.03 mmol) in dioxane (1.5 mL) was heated at 120° C. in a microwave reactor for 90 minutes. The mixture was filtered through diatomeous earth, the filter pad was eluted with methanol. The eluate was concentrated in vacuum and the residue purified by preparative chromatography to give the title compound as a solid, 45 mg (45%).

1. filtrationThe mixture was filtered through diatomeous earth
2. washthe filter pad was eluted with methanol
3. concentrationThe eluate was concentrated in vacuum
4. customthe residue purified by preparative chromatography