反应详情

温度

120 °C

2-Chloro-N-(2-methoxyethyl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine (43 mg, 0.14 mmol), 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (58 mg, 0.29 mmol), cesium carbonate (94 mg, 0.29 mmol), palladium(II) acetate (5 mg, 0.02 mmol), 2-(dicyclohexylphosphino)-biphenyl (8 mg, 0.02 mmol) and dioxane (2 mL) were mixed in a vial and kept under an atmosphere of nitrogen. The mixture was heated in a microwave reactor at 120° C. for 90 min. The reaction mixture was filtered through at pad of diatomeous earth. The filter plug was rinsed with MeOH. The solvents were removed in vacuo and the residue was purified by preparative HPLC to give the title compound as a solid, 34 mg (51%).

1. filtrationThe reaction mixture was filtered through at pad of diatomeous earth
2. washThe filter plug was rinsed with MeOH
3. customThe solvents were removed in vacuo
4. customthe residue was purified by preparative HPLC