反应详情

温度

0 °C

To an ice-cold solution of methylmagnesium bromide (0.71 mL, 1.0 mmol) in THF (6 mL) was added over 5 min a solution of 1-(6-((1,3-difluoropropan-2-yloxy)methyl)-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)pyrimidin-4-yl)ethanone (43 mg, 0.1 mmol) of in THF (3 mL). The reaction was stirred at 0° C. for 30 minutes. Ammonium chloride (sat, aq) was added. The solvent volume was reduced by evaporation. DCM was added and the phases were separated. The organic phase was concentrated and the residue was purified by preparative HPLC to give the title compound as a dry film (34 mg, 76%).

1. customThe solvent volume was reduced by evaporation
2. additionDCM was added
3. customthe phases were separated
4. concentrationThe organic phase was concentrated
5. customthe residue was purified by preparative HPLC