反应详情

温度

50 °C

To the solution of 2-amino-4,6-diisopropoxy-nicotinic acid methyl ester (1.6 g, 5.97 mmol) in methanol (9.0 mL) and water (1.0 mL), was added lithium hydroxide (750 mg, 17.91 mmol). The reaction mixture was heated to 50° C. for 8 hours. The solvent was removed; the residue was diluted with water and neutralized with 2 N HCl. The product was extracted with ethyl acetate (3×100 mL). The combined organic layer was washed with water, then brine, dried over Na2SO4, and evaporated, to give crude 2-amino-4,6-diisopropoxy-nicotinic acid as a light yellow solid. Yield: 1.48 g (98%, crude).

1. customThe solvent was removed
2. additionthe residue was diluted with water and neutralized with 2 N HCl
3. extractionThe product was extracted with ethyl acetate (3×100 mL)
4. washThe combined organic layer was washed with water
5. dry with materialbrine, dried over Na2SO4
6. customevaporated