Formaldehyde → 3-(Hydroxymethyl)benzoselenazolinone

HRID 5918Notes

Reaction equation

HRID 5918 reaction equation
[Se:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH2:10]=[O:11].C[OH:13]>O>[OH:11][CH2:10][N:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[Se:1](=[O:13])[CH2:2]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 887MethanolHCID 136087Benzoselenazole

Product 1

HCID 867472283-(Hydroxymethyl)benzoselenazolinone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

2 grams (0.01 mol) of benzoselenazoline, 2 cm3 (0.02 mol) of aqueous formaldehyde solution and 2 cm3 of methanol are introduced into a ground-necked flask. The mixture is brought to reflux two hours. After cooling to 40° C. 20 cm3 of water are added. The mixture is allowed to cool and the product is drained, washed with water, dried and recrystallized in cyclohexane.

Workup

  1. temperatureto reflux two hours
  2. temperatureto cool
  3. washwashed with water
  4. customdried
  5. customrecrystallized in cyclohexane

Sources & evidence

ORD record
ord-5d28e8e0676841e598914b8d0977a4cb
Source dataset
uspto-grants-1993_09
Patent number
US05246951

Reaction notes

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