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HRID591869

反应详情

EQUATION

反应方程式

HRID 591869 的结构方程式

REACTANTS

反应物

3
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CC[C@H]1[C@@H](O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12
HCID447715

Obeticholic acid

C26H44O4

结构：C/C=C1\C(=O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)OC)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12
HCID86706182

Cholan-24-oic acid, 6-ethylidene-3-hydroxy-7-oxo-, methyl ester, (3α,5β,6Z)-

C27H42O4

PRODUCTS

生成物

1
结构：C/C=C1\C(=O)[C@@H]2[C@H](CC[C@]3(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]23)[C@@]2(C)CC[C@@H](O)C[C@@H]12
HCID86706181

未命名化合物

PROCEDURE

实验过程

The present invention relates to a process for preparing obeticholic acid Form 1, wherein reacting E- or E/Z-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid methyl ester with NaOH to form E- or E/Z-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid is carried out at a temperature at about 20° C. to about 60° C.