HRID591920

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31244

4-Methoxybenzaldehyde

C8H8O2

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2

HCID117701912

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F

HCID178513995

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2nc3c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c(Cl)cnc3[nH]2)cc1

HCID178488907

未命名化合物

收率 16%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 4-methoxybenzaldehyde were reacted to produce the title compound (16%). 1H NMR (d-chloroform): 15.54 (br s, 1H) 8.23 (d, J=9 Hz, 1H), 8.06 (d, J=9 Hz, 2H), 7.79 (s, 1H), 7.06 (d, J=9 Hz, 2H), 6.51 (m, 1H), 6.42 (m, 1H), 5.86 (br s, 1H), 5.46 (br s, 1H), 5.39 (t, J=8 Hz, 1H), 3.91 (s, 3H), 3.17 (s, 1H), 3.05 (s, 1H), 2.68 (d, J=9 Hz, 1H), 2.33 (d, J=9 Hz, 1H), 1.68 (d, J=10 Hz, 1H). MS: 466.07 (M+H). HPLC retention time: 2.42 minutes (G Method).