HRID591923

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8658

2-Methoxybenzaldehyde

C8H8O2

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2

HCID117701912

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F

HCID178513995

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1-c1nc2c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c(Cl)cnc2[nH]1

HCID178489350

未命名化合物

收率 96%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-methoxybenzaldehyde were reacted to produce the title compound (96%). 1H NMR (d-chloroform): 13.89 (br s, 1H) 8.31 (dd, J=1.8 Hz, 1H), 8.10 (d, J=9 Hz, 1H), 7.84 (s, 1H), 7.46 (m, 1H), 7.10 (t, J=8 Hz, 1H), 7.04 (d, J=8 Hz, 1H), 6.49 (m, 1H), 6.43 (m, 1H), 6.07 (br s, 1H), 5.60 (br s, 1H), 5.39 (t, J=8 Hz, 1H), 4.15 (s, 3H), 3.16 (s, 1H), 3.01 (s, 1H), 2.73 (d, J=9 Hz, 1H), 2.33 (d, J=9 Hz, 1H), 1.67 (d, J=9 Hz, 1H). MS: 411.04 (M+H). HPLC retention time: 2.58 minutes (G Method).