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HRID591931

反应详情

EQUATION

反应方程式

HRID 591931 的结构方程式

REACTANTS

反应物

3
结构：COc1cc(N2CCOCC2)ccc1C=O
HCID976800

2-Methoxy-4-morpholin-4-yl-benzaldehyde

C12H15NO3

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2
HCID117701912

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F
HCID178513995

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(N2CCOCC2)ccc1-c1nc2c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c(Cl)cnc2[nH]1
HCID178493033

未命名化合物

收率 90%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-Methoxy-4-morpholin-4-yl-benzaldehyde were reacted to produce the title compound (90%). 1H NMR (d-chloroform): 13.72 (br s, 1H), 8.19 (d, J=8 Hz, 1H), 7.81 (s, 1H), 7.76 (d, J=9 Hz, 1H), 6.62 (dd, J=2.9 Hz, 1H), 6.47 (m, 2H), 6.40 (dd, J=2.6 Hz, 1H), 5.95 (br s, 1H), 5.48 (br s, 1H), 5.42 (d, J=8 Hz, 1H), 4.15 (s, 3H), 3.91 (t, J=5 Hz, 4H), 3.33 (t, J=5 Hz, 4H), 3.16 (s, 1H), 3.02 (s, 1H), 2.71 (d, J=8 Hz, 1H), 2.34 (d, J=9 Hz, 1H), 1.69 (d, J=9 Hz, 1H). MS: 496.06 (M+H). HPLC retention time: 2.48 minutes (G Method).