2-Methoxy-4-morpholin-4-yl-benzaldehyde → HCID 178493033, compound

Participants

Reaction Steps

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-Methoxy-4-morpholin-4-yl-benzaldehyde were reacted to produce the title compound (90%). 1H NMR (d-chloroform): 13.72 (br s, 1H), 8.19 (d, J=8 Hz, 1H), 7.81 (s, 1H), 7.76 (d, J=9 Hz, 1H), 6.62 (dd, J=2.9 Hz, 1H), 6.47 (m, 2H), 6.40 (dd, J=2.6 Hz, 1H), 5.95 (br s, 1H), 5.48 (br s, 1H), 5.42 (d, J=8 Hz, 1H), 4.15 (s, 3H), 3.91 (t, J=5 Hz, 4H), 3.33 (t, J=5 Hz, 4H), 3.16 (s, 1H), 3.02 (s, 1H), 2.71 (d, J=8 Hz, 1H), 2.34 (d, J=9 Hz, 1H), 1.69 (d, J=9 Hz, 1H). MS: 496.06 (M+H). HPLC retention time: 2.48 minutes (G Method).

Provenance & Evidence