2-Methoxy-4-(4-morpholin-4-yl-piperidin-1-yl)-benzaldehyde → HCID 178492998, compound

Participants

Reaction Steps

In the same fashion as for Compound III, (1R,2R,3S,4S)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-Methoxy-4-(4-morpholin-4-yl-piperidin-1-yl)-benzaldehyde were reacted to produce the title compound (8%). 1H NMR (d-6 DMSO): 12.26 (br s, 1H), 9.70 (br s, 1H), 8.02 (m, 1H), 7.79 (s, 1H), 7.42 (br s, 1H), 7.26 (s, 1H), 6.78 (d, J=9 Hz, 1H), 6.66 (s, 1H), 6.38 (s, 2H), 5.17 (m, 1H), 4.11 (m, 2H), 4.03 (m, 2H), 4.00 (s, 3H), 3.68 (m, 2H), 3.48 (m, 4H), 3.12 (m, 2H), 2.92-2.77 (m, 3H), 2.63 (d, J=8 Hz, 1H), 2.24 (m, 1H), 2.13 (m, 2H), 1.68 (m, 2H), 1.40 (d, J=9 Hz, 1H). MS: 578.20 (M+H). HPLC retention time: 1.92 minutes (G Method).

Provenance & Evidence