2-Methoxy-4-morpholin-4-yl-benzaldehyde → HCID 178493033, compound

Participants

Reaction Steps

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-methoxy-4-morpholin-4-yl-benzaldehyde were reacted to produce the title compound (65%). 1H NMR (d-chloroform): 13.88 (br s, 1H), 8.25 (m, 2H), 7.77 (s, 1H), 7.18 (s, 1H), 7.07 (d, J=7 Hz, 1H), 6.42 (m, 3H), 5.81 (s, 1H), 5.29 (t, J=7 Hz, 1H), 4.53 (d, J=9 Hz, 1H), 4.10-3.94 (m, 10H), 3.68 (m, 1H), 3.35 (m, 1H), 3.16 (s, 1H), 2.92 (s, 1H), 2.77 (d, J=8 Hz, 1H), 2.38 (d, J=9 Hz, 1H), 1.63 (d, J=9 Hz, 1H). MS: 509.16 (M+H). HPLC retention time: 1.82 minutes (G Method).

Provenance & Evidence