3-Pyridinecarboxaldehyde → HCID 178514003, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (75 mg, 0.26 mmol), 3-Pyridinecarboxaldehyde (26.4 uL, 0.281 mmol), and Ammonium acetate (39.4 mg, 0.511 mmol) were reacted to produce 5.5 mg (6%) of the title compound. (300 MHz, DMSO-d6) 13.50 (s, 1H), 9.31 (s, 1H), 8.66 (d, J=5 Hz, 1H), 8.45 (d, J=8 Hz, 1H), 7.99 (s, 1H), 7.78 (s, 1H), 7.59 (q, J=13 Hz, 6 Hz, 1H), 7.29 (d, J=8 Hz, 1H), 7.24 (s, 1H), 6.42 (m, 1H), 6.37 (m, 1H), 5.18 (t, J=17 Hz, 8.5 Hz, 1H), 2.90 (s, 1H), 2.80 (s, 1H), 2.63 (d, J=8 Hz, 1H), 2.24 (d, J=8 Hz, 1H), 1.38 (d, J=8 Hz, 1H). MS=381 (M+H), HPLC: 1.69 min. (G Method)

Provenance & Evidence