Methanol → HCID 89725567, compound

HRID 592070Notes

Reaction equation

HRID 592070 reaction equation
[CH2:1]([CH2:3][CH:4]([NH:7][C:8](=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]=[O:16])[CH:10]=1)[CH2:5][OH:6])C.[OH-:18].[Na+].[CH3:20][OH:21]>>[CH2:3]([C:4]([NH:7][C:8](=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]=[O:16])[CH:10]=1)([CH2:5][OH:6])[C:20]([OH:21])=[O:18])[CH3:1]

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 89726139HCID 89726139, compound

Product 1

HCID 89725567HCID 89725567, compoundYield 100%

Procedure

To a solution of compound 39 (200 mg, 0.75 mmol) in MeOH (2 ml) was added NaOH (120 mg, 3.01 mmol). The reaction mixture was stirred at r.t ° C. for 4 h. checked TLC, starting material consumed, adjust the pH up to 6 using 50% HCl and concentrated under vacuum to obtain 178 mg (100%) a white solid.

Workup

  1. customconsumed
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-023b0967e61c43e7b6dd8d5882e1cefb
Source dataset
uspto-grants-2016_01
Patent number
US09238656B2

Reaction notes

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