4-Formylbenzoic acid → Ethyl 2-(4-formylbenzamido)-3-hydroxypropanoate

HRID 592071Notes

Reaction equation

HRID 592071 reaction equation
[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1)=[O:2].[NH2:12][CH:13]([CH2:19][OH:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15]>>[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:12][CH:13]([CH2:19][OH:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:9])=[CH:10][CH:11]=1)=[O:2]

Participants

3

Reactant 2

HCID 120884-Formylbenzoic acidHCID 410488Ethyl 2-amino-3-hydroxypropanoate

Product 1

HCID 89725943Ethyl 2-(4-formylbenzamido)-3-hydroxypropanoateYield 34%

Procedure

In an analogous manner to 39, 4-formyl benzoic acid (24) (1.0 g, 6.66 mmol) and ethyl 2-amino-3-hydroxypropanoate (975 mg, 7.33 mmol) were reacted to yield 600 mg (34%) of 41 as an off-white sticky solid.

Sources & evidence

ORD record
ord-e422a4522b1845cb85bf71cc7875e3ee
Source dataset
uspto-grants-2016_01
Patent number
US09238656B2

Reaction notes

Loading…