反应详情

tert-butyl 4-(2-(3-formylphenoxy)acetyl)piperazine-1-carboxylate (49)/(5.55 mmol) was taken in DCM and cooled to 0° C. when TFA (5 ml) was added drop wise and then stirred at rt for 16 h when TLC confirmed completion of reaction. The reaction mixture was concentrated and neutralized with satd NaHCO3 solution followed by extraction with DCM. The combined organic extracts was dried, concentrated and used directly for the next step (86%). LCMS: 98.12% (M++1).

1. additionwas added drop wise
2. customcompletion of reaction
3. concentrationThe reaction mixture was concentrated
4. extractionfollowed by extraction with DCM
5. customThe combined organic extracts was dried
6. concentrationconcentrated