3-(2-Oxo-2-(piperazin-1-yl)ethoxy)benzaldehyde → 4-(2-Oxo-2-(piperazin-1-yl)ethoxy)benzaldehyde

HRID 592081Notes

Reaction equation

HRID 592081 reaction equation
[CH:1]([C:3]1[CH:25]=[CH:24][C:6]([O:7][CH2:8][C:9]([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)=[O:10])=[CH:5][CH:4]=1)=[O:2].O=C(N1CCNCC1)COC1C=C(C=CC=1)C=O>>[O:10]=[C:9]([N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)[CH2:8][O:7][C:6]1[CH:5]=[CH:4][C:3]([CH:1]=[O:2])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 897262023-(2-Oxo-2-(piperazin-1-yl)ethoxy)benzaldehydeHCID 89738600Tert-Butyl 4-(2-(4-formylphenoxy)acetyl)piperazine-1-carboxylate

Product 1

HCID 391621774-(2-Oxo-2-(piperazin-1-yl)ethoxy)benzaldehydeYield 60%

Procedure

tert-Butyl 4-(2-(4-formylphenoxy)acetyl)piperazine-1-carboxylate (54) was treated in an analogous manner to compound 50 to yield the desired product (60%) as a pale yellow solid. LCMS: 97% (M++1).

Sources & evidence

ORD record
ord-4a40b16a70194b62bfde025818915928
Source dataset
uspto-grants-2016_01
Patent number
US09238656B2

Reaction notes

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