4-(2-Oxo-2-(piperazin-1-yl)ethoxy)benzaldehyde → 4-(2-(4-(2-Hydroxypropyl)piperazin-1-yl)-2-oxoethoxy)benzaldehyde

HRID 592082Notes

Reaction equation

HRID 592082 reaction equation
[O:1]=[C:2]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1.[OH:19][CH:20]([CH3:40])[CH2:21]N1CCN(C(=O)COC2C=C(C=CC=2)C=O)CC1>>[OH:19][CH:20]([CH3:40])[CH2:21][N:16]1[CH2:17][CH2:18][N:13]([C:2](=[O:1])[CH2:3][O:4][C:5]2[CH:6]=[CH:7][C:8]([CH:9]=[O:10])=[CH:11][CH:12]=2)[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 391621774-(2-Oxo-2-(piperazin-1-yl)ethoxy)benzaldehydeHCID 897258703-(2-(4-(2-Hydroxypropyl)piperazin-1-yl)-2-oxoethoxy)benzaldehyde

Product 1

HCID 897260054-(2-(4-(2-Hydroxypropyl)piperazin-1-yl)-2-oxoethoxy)benzaldehydeYield 66%

Procedure

4-(2-oxo-2-(piperazin-1-yl)ethoxy)benzaldehyde (55) was treated in an analogous manner to compound 51 to yield the desired product (66%) as a colorless oil. LCMS: 96% (M++1).

Sources & evidence

ORD record
ord-5f4e6e61737e4d9ea108f611bc7b0e09
Source dataset
uspto-grants-2016_01
Patent number
US09238656B2

Reaction notes

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